Taking a Back Door to Target Myc
نویسنده
چکیده
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For an LTL (Less-than Truckload) carrier, the allocation of doors at a consolidation facility to outbound trailers assigned to various destinations, and to inbound trailers in the continuous stream arriving from various origins, has a significant impact on its operations, and on the nightly man-hours needed for consolidation. In the past literature door allocations to destinations of outbound t...
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Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...
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The c-myc oncogene is one of the most commonly malfunctioning genes in human cancers, and is an attractive target for anti-gene therapy. Although synthetic oligonucleotides designed to silence c-myc expression via one of its major control elements function well in vitro, their mode of action has been indefinite. Here we show that the targeted control element adopts an intrastrand fold-back DNA ...
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